2011•Journal of Chinese Practical Diagnosis and TherapyRequires access
Prophylactic effect of high-dose methylprednisolone on oxygen free radical in rats with acute spinal cord injury
Jiang Bai-chuan
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Abstract
Objective To investigate the prophylactic effect of high-dose methylprednisolone on oxygen free radical in rats with acute spinal cord injury.Methods Forty SD rats were randomly divided into observation group and control group with 20 rats in each group.The observation group received high-dose methylprednisolone and control group received normal saline 30 minutes before acute spinal cord injury induced by Allen's weight drop.Tarlov motor scale,superoxide dismutase and malondialdehyde were detected 24 and 72 hours after spinal cord injury.Results There was no significant difference in Tarlov motor scale 24 hours after spinal cord injury between two groups.Tarlov motor scale was significantly higher 72 hours after spinal cord injury in the observation group than that in control group.Superoxide dismutase level was obviously higher and malondialdehyde level was lower 24 hours and 72 hours after spinal cord injury in the observation group than that in control group.There were significant differences in superoxide dismutase and malondialdehyde levels between 24 hours and 72 hours in the observation group(P0.01).Conclusion High-dose methylprednisolone can clear oxygen free radical and protect brain nerves in rats with acute spinal cord injury.