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2011•The Chinese Journal of Clinical PharmacologyRequires access

Effects of simvastatin combinate with losartan and fosinopril in the treatment of chronic kidney

Gao Ji-ling

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Abstract

Objective To explore the therapeutic effects of combination of simvastin,losartan and fosinopril in the treatment of chrinic kidney disease(CKD).Methods Sixty-two patients with CKD were randomly divided into two groups,both two groups received conventional therapy then the control group received 50 mg·d-1 of losartan(ACEI),10 mg·d-1 of fosinopril(ARB),while the treated group was added orally 20 mg of simvastatin every night.The blood glucose,blood pressure,Upr and Scr in the patients of two groups were compared before treatment and 3,6 months after treatment.Results The urinary protein level decreased significantly in treated group(P0.05) but unchanged in control group.Conclusion ACEI and ARB combinating with simvastatin may show more protective effects on patients with chronic kidney disease.

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Objective To explore the therapeutic effects of combination of simvastin,losartan and fosinopril in the treatment of chrinic kidney disease(CKD).Methods Sixty-two patients with CKD were randomly divided into two groups,both two groups received conventional therapy then the control group received 50 mg·d-1 of losartan(ACEI),10 mg·d-1 of fosinopril(ARB),while the treated group was added orally 20 mg of simvastatin every night.The blood glucose,blood pressure,Upr and Scr in the patients of two groups were compared before treatment and 3,6 months after treatment.Results The urinary protein level decreased significantly in treated group(P0.05) but unchanged in control group.Conclusion ACEI and ARB combinating with simvastatin may show more protective effects on patients with chronic kidney disease.

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Available abstract

Objective To explore the therapeutic effects of combination of simvastin,losartan and fosinopril in the treatment of chrinic kidney disease(CKD).Methods Sixty-two patients with CKD were randomly divided into two groups,both two groups received conventional therapy then the control group received 50 mg·d-1 of losartan(ACEI),10 mg·d-1 of fosinopril(ARB),while the treated group was added orally 20 mg of simvastatin every night.The blood glucose,blood pressure,Upr and Scr in the patients of two groups were compared before treatment and 3,6 months after treatment.Results The urinary protein level decreased significantly in treated group(P0.05) but unchanged in control group.Conclusion ACEI and ARB combinating with simvastatin may show more protective effects on patients with chronic kidney disease.

Key concepts: Simvastatin, Fosinopril, Losartan, Medicine, Urology, Blood pressure, Kidney, Internal medicine

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Effects of simvastatin combinate with losartan and fosinopril in the treatment of chronic kidney — Research Paper | ScholarLens