2006•Xiandai yufang yixueRequires access

EXPERIMENTAL STUDY ON THE EFFECT OF GASEOUS FORMALDEHYDE ON MICRONUCLEI IN MICE.

Qian Zhao

Abstract

Objective:To explore potential demage effect of gaseous formaldehyde on genetic material of cells.Methods:SPF-class Kun-Ming male mice were used in experiment.The mice were exposed in different concentration of gaseous formaldehyde,the agent was administrated by continuous dynamic inhalation.After finished exposure to formaldehyde for 24 hours,micronucleus rate in bone marrow polychromatic erythrocytes was measured.Exposed for 15 days,the micronucleus rate in sperm cells was measured.Results:Gaseous formaldehyde could induce the increase of micronucleus rate in bone marrow polychromatic erythrocytes and early stage sperm cells all with a dose-dependent relationship between them.it indicates significant genetic toxicity(P0.01)and reproductive toxicity(P0.05;P0.01).Conclusion:Gaseous formaldehyde has significant demage effect on chromsome in body cells and sperm cell.

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Key concepts: Formaldehyde, Micronucleus, Micronucleus test, Sperm, Bone marrow, Toxicity, Andrology, Toxicology