Effects of Aerobic Exercise and Dietary Control on Hemorheology in Type 2 Diabetic Rats and its Mechanism

Objective:To investigate the effects of aerobic exercise combined with dietary control on hemorheology in type 2 diabetic rats and its mechanism.Methods:8 rats were randomly selected rats as normal control group(Control,C) from 62 6-week-old male SD rats,the remaining rats were injected intraperitoneally low-dose streptozotocin based on feeding high-fat diet to establish animal models of type 2 diabetes,and given the aerobic exercise and / or dietary control,hemorheological index,blood glucose(FPG),glycated serum proteins(GSP),triglyceride(TG) and total cholesterol(TC) content were measured after 13 weeks.Results:①After 13 weeks of the establishment of type 2 diabetes model,compared with C group,among the hemorheological indexes in the DM group,whole blood viscosity in middle shear,plasma viscosity,whole blood reduced viscosity in high shear,erythrocyte aggregation index,erythrocyte rigidity index were significantly higher,ESR and erythrocyte degeneration index decreased significantly.Through the double factor variance analysis,13 weeks of moderate-intensity swimming training could decrease the whole blood viscosity under different shear rate type 2 diabetic rats,in particular whole blood viscosity in 1:00 shear had a significant difference(P 0.05);Reduced viscosity in high-shear and low shear(P 0.01) and ESR(P = 0.05) were significantly increased;erythrocyte aggregation index decreased significantly(P 0.01),plasma viscosity,hematocrit,erythrocyte rigidity index,erythrocyte deformability index had some improvement,but there were no significant difference(P 0.05).After the dietary control in type 2 diabetes,the erythrocyte aggregation index decreased significantly,other indicators had some improvement,but there were no significant difference.Aerobic exercise combined with diet control could further reduce the whole blood viscosity in low shear,plasma viscosity,whole blood reduced viscosity in high shear or low shear and erythrocyte aggregation index,and further increased ESR and erythrocyte deformability index in type 2 diabetic rats significantly,they had a significant interaction(P 0.05).②Compared with the C group,FPG,GSP,TC and TG content in DM group were extremely significant increase.By two-way ANOVA analysis shows that aerobic exercise could significantly reduce FPG,GSP and TC levels in T2DM rats,but not significantly reduced TG content.Dietary control could significantly reduce serum GSP,TG and TC content in T2DM rats.Aerobic exercise combined with dietary control had a significant interaction on further reducing serum TC content,but no significant interaction on further reducing FPG,GSP and TG content in the T2DM rats.Conclusion:①Hyperviscosity was occurred in type 2 diabetes,which showed concentration,coagulation,accumulation and sticky state.Aerobic exercise could improve hemorheological index in type 2 diabetic rats,significantly lower hyperviscosity.Relying on dietary control simply could not effectively improve hemorheological index in type 2 diabetic rats.Aerobic exercise training combined with dietary control was more effective to improve hemorheological index in type 2 diabetic rats to some extent.②Glucose and lipid metabolism disorders was an important mechanism for hyperviscosity,the long-term aerobic exercise and dietary control could improve blood rheology by improving the disorders of the glucose and lipid metabolism in diabetic rats.