Effect of Invasive Mechanical Ventilation Applied at Different Occasions on Acute Exacerbation of COPD Complicated with Severe Respiratory Failure

Objective To investigate the appropriate occasion for application of invasive mechanical ventilation to treat acute exacerbation of chronic obstructive pulmonary diseases(COPD) complicated with severe respiratory failure in ICU. Methods The data of 62 patients with acute exacerbation of COPD complicated by severe respiratory failure were retrospectively analyzed.According to the time applying invasive mechanical ventilation,all the patients were divided as early mechanical ventilation group(A) and delayed mechanical ventilation group(B).They were all given basic therapies including antibiotics,spasmolytics,anti-asthmatics,expectorants,sputum aspiration,correcting electrolyte imbalances,and nutrition supporting.The relevant indexes of arterial blood gas analyses,and the time applying invasive mechanical ventilation,total duration of mechanical ventilation,and hospitalization days in ICU of the patients in the two groups were comparatively analyzed. Results The mean of oxygenation index(PaO2/FiO2) in group A was significantly higher than that in group B,and the mean of PaCO2 was significantly lower(P0.05).The time of invasive mechanical ventilation,total duration of mechanical ventilation and ICU hospitalization days in group A were more less than those in group B(P0.05). Conclusion An early tracheal intubation could improve respiratory failure,reduce the durations of invasive ventilation and ICU hospitalization for a patient with acute exacerbation of COPD complicated with severe respiratory failure.