2009•PubMedRequires access

[Study on the expression of BDNF in human gliomas].

Qi Yan, Hualin Yu, Jingtao Li

Abstract

OBJECTIVE: To investigate the expression of brain-derived neurotrophic factors (BDNF) in gliomas of human, and explore the relation between BDNF and pathologic grading and tumorigenesis of gliomas. METHODS: Immunohistochemistry (SP) and Western blot were applied to evaluate the expression of BDNF in 5 cases of normal controls and 20 cases of gliomas from different pathologic grading. RESULTS: The expression of BDNF was observed mainly occurred in the cytoplasm of both normal brain tissues and gliomas. Western blot analysis showed that the expression level of BDNF in gliomas was significantly higher than that of normal controls (P<0.05), and a gradually increased expression of BDNF in vary pathologic grading (grade I, II, III, IV) gliomas was also observed. CONCLUSION: The expression of BDNF in gliomas of human was greatly upregulated, indicating BDNF may play an important role in the tumorigenesis of gliomas, and relate with pathologic grading.

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Key concepts: Grading (engineering), Brain-derived neurotrophic factor, Immunohistochemistry, Western blot, Carcinogenesis, Glioma, Neurotrophic factors, Pathology