2010•Chinese Journal of Neurosurgical Disease ResearchRequires access
Expression and clinical significance of BDNF in human glioma
Yuan Deliang
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Abstract
Objective To investigate the expression and significance of brain derived neurotrophic factors(BDNF) in human gliomas and explore the relationship between BDNF and pathological grades of gliomas.Methods Immunohistochemistry and Western blot were applied to evaluate the expression of BDNF in 5 cases of normal brain tissues and 80 glioma samples of different pathological grades.Results The expression of BDNF was observed mainly in the cytoplasm of both normal brain tissues and glioma tissues.Immunohistochemistry and Western blot showed that the expression level of BDNF in gliomas was significantly higher than that of normal brain tissues(P0.05),and the positive expression rate of BDNF gradually increased with the increase of pathological grade of glioma(P0.05).Conclusion The expression level of BDNF is correlated positively with the tumors' pathological grade,which indicates BDNF may play an important role in the tumorigenesis of gliomas.