Pharmacokinetics of ribavirin tablets in healthy volunteers

Objective To evaluate the safety and pharmacokinetic parameters of a domestic ribavirin tablets in Chinese healthy male volunteers after administered 300 mg oral dosage. Methods Twenty healthy Chinese volunteers were given a single oral dose domestic ribavirin tablet. The concentration of ribavirin in blood plasma was measured by an validated LC-MS/MS method and were assessed with non-compartment model to obtain the pharmacokinetic parameters.Results The pharmacokinetic parameters of ribavirin tablets for orally administered 300 mg dosage were as follows: AUC0-t was(5584.91±1659.34)ng.h.mL-1; AUC0-∞ was(7166.33±2224.28)ng.h.mL-1;Cmax was(442.60±148.97)ng.mL-1;tmax was(1.40±1.20)h;t1/2 was(22.93±6.38)h;Ke was (0.03±0.01) h-1;Vd was (1484.37±491.50);CL was (45.67±13.90) L.h-1.Conclusion The results showed that there was no significant difference in pharmacokinetics compared with the reference which had reported 2-5 .