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2005•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Pharmacokinetics and Bioequivalence of Ribavirin in Healthy Volunteers

Wen Ai

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Abstract

Aim To study the pharmacokinetics and bioequivalence of ribavirin tablets in healthy volunteers.Methods A single oral dose of two kinds of ribavirin was given to 24 healthy volunteers in a randomized two-period crossover study.The concentrations of ribavirin in plasma were determined by the liquid chromatography-tandem mass spectrometry (LC-MS-MS) method.Results The main pharmacokinetic parameters of test and reference were as follows:T_max was 3.55±3.06 and 2.84±2.89h,C_max 214.12±89.21 and 223.89±116.83μg·L~-1,AUC_(0-72h) 5 252.63±1 896.66 and 5 239.36±2 708.07μg·h·L~-1,respectively.The relative bioavailability of the tested drug was 110.5%.Conclusion The two kinds of ribavirin were bioequivalent in healthy volunteers.

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Aim To study the pharmacokinetics and bioequivalence of ribavirin tablets in healthy volunteers.Methods A single oral dose of two kinds of ribavirin was given to 24 healthy volunteers in a randomized two-period crossover study.The concentrations of ribavirin in plasma were determined by the liquid chromatography-tandem mass spectrometry (LC-MS-MS) method.Results The main pharmacokinetic parameters of test and reference were as follows:T_max was 3.55±3.06 and 2.84±2.89h,C_max 214.12±89.21 and 223.89±116.83μg·L~-1,AUC_(0-72h) 5 252.63±1 896.66 and 5 239.36±2 708.07μg·h·L~-1,respectively.The relative bioavailability of the tested drug was 110.5%.Conclusion The two kinds of ribavirin were bioequivalent in healthy volunteers.

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Available abstract

Aim To study the pharmacokinetics and bioequivalence of ribavirin tablets in healthy volunteers.Methods A single oral dose of two kinds of ribavirin was given to 24 healthy volunteers in a randomized two-period crossover study.The concentrations of ribavirin in plasma were determined by the liquid chromatography-tandem mass spectrometry (LC-MS-MS) method.Results The main pharmacokinetic parameters of test and reference were as follows:T_max was 3.55±3.06 and 2.84±2.89h,C_max 214.12±89.21 and 223.89±116.83μg·L~-1,AUC_(0-72h) 5 252.63±1 896.66 and 5 239.36±2 708.07μg·h·L~-1,respectively.The relative bioavailability of the tested drug was 110.5%.Conclusion The two kinds of ribavirin were bioequivalent in healthy volunteers.

Key concepts: Bioequivalence, Pharmacokinetics, Ribavirin, Bioavailability, Crossover study, Medicine, Pharmacology, Chromatography

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