Expression and Significance of MiR-29a in Cervical Cancer Tissues

Objective To investigate the expression of miR-29a and its association with clinicopathologic features in cervical cancer.Methods Expression of miR-29a in 56 cervical cancer and 20 normal control tissues were examined by real-time RTPCR.The relationship between miR-29a expression and various clinicopathological characteristics in cervical cancer were analyzed.Results The miR-29a was specifically amplified by real-time RT-PCR.Its expression in cervical cancer tissues was significantly lower than that in normal cervical tissues(P 0.01).The expression of miR-29a in FIGO stage Ⅱa was significantly lower than that in stage Ia and stage Ib(P 0.01).The level of miR-29a is not relevant with patient age,tumor size,general type and pathological grading of cervical cancer(P 0.05).Conclusion The miR-29a is a valuable marker and may be a potential therapeutic target of cervical cancer.