Effects of gastric bypass on pancreatic functions of diabetes mellitus in rats

【Objective】 To investigate the therapeutic effects of gastric bypass on blood glucose and pancreatic functions of diabetes mellitus in rats.【Methods】 A total of 54 adult male SD rats were used in this experiment.Diabetes mellitus animal models were induced with high fat diet and injected 35 mg/kg Streptozotocin(STZ).After 1 week,4 weeks and 8 weeks gastric bypass,the level of fasting plasma glucose(FPG) and serum insulin was detected,the expression of insulin were observed by immunohistochemistry.【Results】 After 1 week,4 weeks and 8 weeks of surgery,the level of FPG in experimental group was lower than control group(P 0.05).After 4 weeks and 8 weeks of surgery,the level of serum insulin and β islet cells share ratio of Islet of experimental group was higher than control group(P 0.05).8 weeks later,the level of serum insulin and β islet cells share ratio of islet compared no significant difference with 4 weeks after surgery.【Conclusion】 Gastric bypass is effective in terms of glucose control in non-obese T2DM through increasing insulin secretion and decreasing insulin resistance probably.