Study on the Correlation of Serum Adiponectin and Resistin with Gestational Diabetes Mellitus Pregnant Women

Objective To investigate serum concentration of adiponectin and resistin and their correlation with insulin resistance in pregnant women with gestational diabetes mellitus (GDM);To investigate the correlation between adiponectin and resistin of GDM.Methods 50-g glucose screening test was conducted for many cases pregnant women at 28～32 weeks of pregnancy.If the blood sugar value was abnormal to examine with oral glucose tolerance test (OGTT).According to the result of OGTT,three groups were divided.The first group was 30 cases of normal glucose tolerance (NGT),the second group was 21 cases of impaired glucose tolerance (GIGT),the third group was 32 cases of gestational diabetes mellitus (GDM).ELISA technique was employed to determine the serum adiponectin and resistin concentration,at the same time the fasting blood glucose,insulin concentration were detected.Insulin resistance index was calculated by HOMA,and the dependability of index was analyzed.Results (1) In the NGT,GIGT and GDM groups the serum adiponectin level tended to decrease gradually in turn(P 0.01),but the level of serum resistin tended to advance gradually in turn(P 0.01),especially in the GDM.(2) Serum adiponectin correlated negatively with insulin resistance index,fasting blood glucose and BMI(P 0.01),whereas resistin correlated positively with the index above(P 0.01),serum adiponectin correlated negatively with resistin of GDM(P 0.01).Conclusion Adiponectin is one of the protection factors of GDM;resistin promotes the development of GDM by enhance insulin resistance index.It could be used as a new sensitive indicator to evaluate the degree of insulin resistance in GDM and it can be a new target of treatment of GDM.