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2004•Zhongguo yaoke daxue xuebaoRequires access

Antibacterial Study of Tanshinone IIA

Jia Zhu

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Abstract

AIM:Why cannot tanshinone ⅡA show antibacterial activity against broad range and what is the main reason?METHOD:Only displacing the hydrophobic solvent CHCl 3 by a hydrophilic solvent DMF in the agar diffusion test procedure,and detecting that how the tanshinone ⅡA will be in the antibacterial activity with some test organisms.CONCLUSION:The agar diffusion test procedure is not fit for the lipoid soluble compound isolated from Traditional Chinese Medicine such as tanshinone ⅡA because the lipoid compound cannot diffuse from paper disc onto the agar. If using the DMF as a solvent tanshinone ⅡA had antibacterial activity against a broad range of bacteria. Minimum inhibitory concentration of tanshinone ⅡA to Escherichia coli ATCC 25922 is 50 μg/ml;and to Staph.aureus ATCC 25923 is 100 μg/ml;to P.Aeruginosa ATCC 27853 is 50 μg/ml;to Hemolytic Strepococus is 12.5 μg/ml.

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AIM:Why cannot tanshinone ⅡA show antibacterial activity against broad range and what is the main reason?METHOD:Only displacing the hydrophobic solvent CHCl 3 by a hydrophilic solvent DMF in the agar diffusion test procedure,and detecting that how the tanshinone ⅡA will be in the antibacterial activity with some test organisms.CONCLUSION:The agar diffusion test procedure is not fit for the lipoid soluble compound isolated from Traditional Chinese Medicine such as tanshinone ⅡA because the lipoid compound cannot diffuse from paper disc onto the agar. If using the DMF as a solvent tanshinone ⅡA had antibacterial activity against a broad range of bacteria. Minimum inhibitory concentration of tanshinone ⅡA to Escherichia coli ATCC 25922 is 50 μg/ml;and to Staph.aureus ATCC 25923 is 100 μg/ml;to P.Aeruginosa ATCC 27853 is 50 μg/ml;to Hemolytic Strepococus is 12.5 μg/ml.

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Available abstract

AIM:Why cannot tanshinone ⅡA show antibacterial activity against broad range and what is the main reason?METHOD:Only displacing the hydrophobic solvent CHCl 3 by a hydrophilic solvent DMF in the agar diffusion test procedure,and detecting that how the tanshinone ⅡA will be in the antibacterial activity with some test organisms.CONCLUSION:The agar diffusion test procedure is not fit for the lipoid soluble compound isolated from Traditional Chinese Medicine such as tanshinone ⅡA because the lipoid compound cannot diffuse from paper disc onto the agar. If using the DMF as a solvent tanshinone ⅡA had antibacterial activity against a broad range of bacteria. Minimum inhibitory concentration of tanshinone ⅡA to Escherichia coli ATCC 25922 is 50 μg/ml;and to Staph.aureus ATCC 25923 is 100 μg/ml;to P.Aeruginosa ATCC 27853 is 50 μg/ml;to Hemolytic Strepococus is 12.5 μg/ml.

Key concepts: Agar, Antibacterial activity, Agar diffusion test, Solvent, Chemistry, Minimum inhibitory concentration, Escherichia coli, Bacteria

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