Curative Effects of L-Carnitine on Neonates with Myocardial Injury Caused by Asphyxia

Objective To explere the curative effects of L-carnitine on neonates with myocardial injury caused by asphyxia.Methods Ninety-one neonates with myocardial injury caused by asphyxia were randomly divided into L-carnitine treatment group(48 cases) and control group(43 cases).The patients in control group were received routine treatment;the patients in treatment group were given L-carnitine 0.1 g/(kg·d) on the basis of routine treatment for 10 days.Symptoms and physical signs were observed pretreatment and during the time of therapy.Before and after the treatment,serum MB isoenzyme of creatine kinase(CK-MB) and aspartate aminotransferase(AST) were mea-sured with immunosuppression and enzyme rate respectively,and serum albumin and prealbumin were detected with the method of bromcresol green chromatometry and immunoturbidimetry,respectively.Results Clinical effective rate of the treatment group(91.67%)was higher than that of control group(74.42%)(P0.05).The treatment group showed a shorter duration of the heart rate recovery[(3.18±1.10) d],compared with control group[(4.32±1.43) d](P0.05).After treatment courses,CK-MB and AST in the treatment group were(22.48±4.72) U/L and(42.18±9.27) U/L,respectively,significantly closer to normal(Pa0.05),compared with control group[(29.06±6.10) U/L,(51.31±11.81) U/L].Compared with control group[(110.73±25.46) mg/L],higher serum level of prealbumin post-treatment was seen in the treatment group[(125.25±30.64) mg/L](P0.05).Higher serum level of albumin post-treatment was also found in the treatment group[(38.58±6.56) g/L]compared with the control group[(35.79±6.44) g/L](P0.05).Conclusion It is very effective of using L-carnitine to treat myocardial injury caused by asphyxia in neonates.