The preventive effect of palonosetron hydrochloride on nausea and vomiting induced by breast cancer chemotherapy with cyclophosphamide,pharmorubicin and 5-fluorouracil

Objective:Palonosetron hydrochloride and tropisetron hydrochloride were used to prevent the nausea and vomiting caused by breast cancer chemotherapy with cyclophosphamide,pharmorubicin and 5-fluorouracil and the efficacy was investigated.Methods:42 cases with breast cancer receiving chemotherapy with cyclophosphamide,pharmorubicin and 5-fluorouracil after operation were enrolled in this trial.All cases were designed with self-across comparison methods and were randomized into two groups AB group or BA group.Palonosetron hydrochloride was administered to prevent the nausea and vomiting before chemotherapy in AB group when the patients received first course of chemotherapy,tropisetron hydrochloride was administrated during the second course of chemotherapy; On the contrary,tropisetron hydrochloride was administered in BA group when the patients received first course of chemotherapy,palonosetron hydrochloride was administered during the second course of chemotherapy.The situation of nausea and vomiting and adverse reactions were observed and recorded respectively in a period of 4 days after chemotherapy.Results:When palonosetron hydrochloride was administered to prevent the acute vomiting,there were 25 cases with grade 0,13 cases with grade 1,3 cases with grade 2,1 case with grade 3,0 case with grade 4 respectively;while tropisetron hydrochloride was administered to prevent the acute vomiting,there were 21 cases with grade 0,12 cases with grade 1,5cases with grade 2,3 cases with grade 3,1 case with grade 4 respectively;palonosetron hydrochloride was superior to tropisetron hydrochloride in controlling acute vomiting(P0.05).When palonosetron hydrochloride was administered to prevent the delayed vomiting,there were 20 cases with grade 0,14 cases with grade 1,7cases with grade 2,1 case with grade 3,0 case with grade 4 respectively;while tropisetron hydrochloride was administered to prevent the delayed vomiting,there were 13 cases with grade 0,15 cases with grade 1,9cases with grade 2,4 cases with grade 3,1 case with grade 4 respectively;palonosetron hydrochloride was superior to tropisetron hydrochloride in controlling delayed vomiting(P0.01).There was no significant difference in the adverse reactions and controlling nausea caused by chemotherapy between palonosetron hydrochloride and tropisetron hydrochloride(P0.05).Conclusion:Palonosetron hydrochloride was superior to tropisetron hydrochloride in controlling acute and delayed vomiting caused by breast cancer chemotherapy with cyclophosphamide,pharmorubicin and 5-fluorouracil and had few side reaction,and should be advocated in clinical practice.