Randomized controlled study on efficacy and safety of domestic palonosetron hydrochloride in prevention of nausea and vomiting induced by chemotherapy

Objective To assess the efficacy and safety of palonosetron for preventing nausea and vomiting caused by high emetic risk chemotherapy.Methods Malignant patients who were accord with the standard were assigned to groups AB and BA randomly to receive a single dose of palonosetron or tropisetron 30 min before chemotherapy.The nausea and vomiting episodes and adverse effects within 5 days after chemotherapy were observed.Results A total of 24 patients were enrolled and only 18 patients could be evaluated.The complete control rates and efficacy control rates of acute nausea,delayed nausea,acute vomiting,and the complete control rate of delayed vomiting showed no significant differences.The efficacy control rate of delayed vomiting with palonosetron was obviously higher than that with tropisetron.The adverse reactions of the two drugs were fewer and mild without statistic difference.Conclusion For high emetic risk chemotherapy,palonosetron is similar to tropisetron for preventing nausea and acute vomiting.But it is superior to tropisetron for preventing delayed vomiting with fewer and mild side effects.