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2010•Journal of Oral Science ResearchRequires access

Observation and Discussion on Ultrastructure of Platelet-Rich Fibrin

Yanqi Li

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Abstract

Objective:To observe microstructure and ultrastructure of platelet-rich fibrin and to investigate its potential biological characteristics. Methods:In the experimental group 6 healthy donors were randomly divided into 3 groups. Whole blood was collected from them to prepare PRF,and then samples were observed by optical microscope,SEM and TEM. Two donors' whole blood in control group was collected to prepare PRP,and then the samples were observed by SEM. Results:In PRF,fibrins get together for a porous three-dimensional network structure,lots of platelets and leucocytes were trapped in the fibrin-net structure,and some α-granules in platelet were broken. In PRP platelets spread lots of pseudo pods and accumulated in a big cluster,a little leucocytes scatter. Conclusion:Fibrin network structure of PRF is the main structural foundation for prolonging the effect of cytokines. Lots of leucocytes in PRF may have plenty of immunological value.

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What this paper is about

Objective:To observe microstructure and ultrastructure of platelet-rich fibrin and to investigate its potential biological characteristics. Methods:In the experimental group 6 healthy donors were randomly divided into 3 groups. Whole blood was collected from them to prepare PRF,and then samples were observed by optical microscope,SEM and TEM. Two donors' whole blood in control group was collected to prepare PRP,and then the samples were observed by SEM. Results:In PRF,fibrins get together for a porous three-dimensional network structure,lots of platelets and leucocytes were trapped in the fibrin-net structure,and some α-granules in platelet were broken. In PRP platelets spread lots of pseudo pods and accumulated in a big cluster,a little leucocytes scatter. Conclusion:Fibrin network structure of PRF is the main structural foundation for prolonging the effect of cytokines. Lots of leucocytes in PRF may have plenty of immunological value.

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Available abstract

Objective:To observe microstructure and ultrastructure of platelet-rich fibrin and to investigate its potential biological characteristics. Methods:In the experimental group 6 healthy donors were randomly divided into 3 groups. Whole blood was collected from them to prepare PRF,and then samples were observed by optical microscope,SEM and TEM. Two donors' whole blood in control group was collected to prepare PRP,and then the samples were observed by SEM. Results:In PRF,fibrins get together for a porous three-dimensional network structure,lots of platelets and leucocytes were trapped in the fibrin-net structure,and some α-granules in platelet were broken. In PRP platelets spread lots of pseudo pods and accumulated in a big cluster,a little leucocytes scatter. Conclusion:Fibrin network structure of PRF is the main structural foundation for prolonging the effect of cytokines. Lots of leucocytes in PRF may have plenty of immunological value.

Key concepts: Platelet-rich fibrin, Fibrin, Platelet, Ultrastructure, Chemistry, Pathology, Medicine, Immunology

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