ScholarLens Back to search
2002•Zhongguo aizheng zazhiRequires access

Expression of resistance-related genes in lung carcinomas tissue and its clinical significance

Lu Mei

Open publisher page 0 citations

Abstract

Purpose:To investigate the expression of resistance related genes in lung carcinomas tissues and its clinical significance.Methods:eighty one samples from untreated lung carcinoma patients were examined by immunohistochemistry technique. Results:The positive rates of P gp ?MRP and LRP were 61%,49%, 65%., 56%,22%,44% in NSCLC and SCLC respectively. The positive rates of P gp?MRP and LRP were not correlated to TNM staging( P 0.05).The patients with positive P gp and LRP expression responded more poorly to chemotherapy than those with negative P gp and LRP expression ( P 0.05). Conclusions:Multidrug resistance of lung cancer was a process of polygene and multiple pathways. Examination of resistance related genes in lung carcinomas tissues can assist in the judgment of effectiveness of chemotherapeutics and prognosis.

About this research paper

What this paper is about

Purpose:To investigate the expression of resistance related genes in lung carcinomas tissues and its clinical significance.Methods:eighty one samples from untreated lung carcinoma patients were examined by immunohistochemistry technique. Results:The positive rates of P gp ?MRP and LRP were 61%,49%, 65%., 56%,22%,44% in NSCLC and SCLC respectively. The positive rates of P gp?MRP and LRP were not correlated to TNM staging( P 0.05).The patients with positive P gp and LRP expression responded more poorly to chemotherapy than those with negative P gp and LRP expression ( P 0.05). Conclusions:Multidrug resistance of lung cancer was a process of polygene and multiple pathways. Examination of resistance related genes in lung carcinomas tissues can assist in the judgment of effectiveness of chemotherapeutics and prognosis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Purpose:To investigate the expression of resistance related genes in lung carcinomas tissues and its clinical significance.Methods:eighty one samples from untreated lung carcinoma patients were examined by immunohistochemistry technique. Results:The positive rates of P gp ?MRP and LRP were 61%,49%, 65%., 56%,22%,44% in NSCLC and SCLC respectively. The positive rates of P gp?MRP and LRP were not correlated to TNM staging( P 0.05).The patients with positive P gp and LRP expression responded more poorly to chemotherapy than those with negative P gp and LRP expression ( P 0.05). Conclusions:Multidrug resistance of lung cancer was a process of polygene and multiple pathways. Examination of resistance related genes in lung carcinomas tissues can assist in the judgment of effectiveness of chemotherapeutics and prognosis.

Key concepts: Lung cancer, Immunohistochemistry, Clinical significance, Medicine, Lung, Carcinoma, Chemotherapy, Multiple drug resistance

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression of resistance-related genes in lung carcinomas tissue and its clinical significance — Research Paper | ScholarLens