The Effect of Acupuncture on Bax of Hippocampal Neurons in Ischemia Side and the Relationship Between the Effect and Learning and Memory in Cerebral Infarction Rats

Objective:To observe the effect of acupuncture on Bax of hippocampal neurons in ischemia side and Learning and Memory in cerebral infarction rats.Methods:Of 80 male rats,48 rats were made into cerebral infarction models from by occlusion of the middle cerebral artery with clew.These were then divided randomly into 2 groups:control group(24 rats) and acupuncture group(24 rats).The expression of Bax of hippocampal neurons in ischemia side were detected by immuno-histochemistry,and the ability of Learning and Memory were evaluated by Y-maze.The data were analyzed by one-way analysis of variance,T-test and q test.Results:In 1,2 and 3 weeks group,the times of Y-maze,the positive expression of Bax and apoptosis index in hippocampus CA1 region in control groups exceeded that of acupuncture groups(P0.05).Conclusion:The ability of learning and memory in cerebral infarction rats was improved by acupuncture,which may be accomplished by decreasing Bax expression in hippocampus CA1 region,then protecting hippocampus cells from apoptosis.