Clinical and pathological features of perivascular epithelioid cell tumor of 15 cases

Purpose To investigate the clinicopathologic features and immunological phenotype of perivascular epithelioid cell tumor(PEComa).Methods Immunohistochemistry and special staining were used to observe the 15 cases of PEComa in order to further recognize and understand the tumor.Results Among 15 patients,13 were female,and no postoperative recurrence.Tumors can occur in any part of the body,but mostly in liver and kidney.Most of these tumors were encapsulated,solid,and bleeding.The growth of tumor cells around the blood vessels is characteristic histological changes.PAS staining revealed that the tumor cells had the deposition of glycogen material,elastic fiber staining revealed that the tumor blood vessels were short of elastic layer.Immunohistochemical study found all tumors were significantly expressed by HMB-45,Melan-A,SMA,but the positive rate of Ki-67 is not high.Conclusion PEComa is a group of malignant potential tumor,almost occurs in women and derives from perivascular epithelioid cells.Most tumors show benign process and have a good prognosis,but rarely some cases can metastasiize,the prognosis is poor.Immunohistochemical detection may suggest the tissue origin,biological behavior of PEComa and contribute to diagnosis.