The Efficacy and Safety of Two Dosages of Simvastatin in Patients with Hyperlipidemia

Objective To investigate the efficacy and safety of simvastatin in patients with hyperlipidemia. Methods 76 patients with hyperlipidemia were randomized to the simvastatin 20 mg group(n=38)or simvastatin 40 mg group (n=38). All the patients took the drug orally before sleep for eight weeks. Serum TC, LDL-C, CRP, CK, liver function and renal function were measured before and after the treatment. The side effects such as myalgia and gastrointestinal symptom were also monitored. Results After treatment, serum TC, LDL-C and CRP were significantly reduced in both groups (P0.01), and there was a significant difference between the two groups (P0.01). Conclusion Simvastatin is efficient to patients with hyperlipidemia, intensive lipid-adjusting therapy is effective and safe to reduce the serum levels of lipid. No side effect such as muscle dissolution or hepatorenal abnormal was observed.