A comparative study of mycophenolate mofetil versus leflunomide in the treatment with refractory nephropathy syndrome

Objective To compare the efficecy and side effects of mycophenolate mofetil (MMF) and leflunomide therapy in the treatment of refractory nephropathy syndrome.Methods Thirty two Refractory nephropathy syndrome patients were treated With mycophenolate mofetil and another thirty two patient treated with leflumomide, They were divided into MMF or leflunomide. All patients received Prednisone. Clinical data were observed in the 2nd、4th、6th、8th、10th and 12th week. The clinical and pathological parameters were compared between The two groups. Results After receiving mycophenolate mofetil theraphy, the proteinuric was decreased significanly (P0.01);serum albumin was increased significantly (P0.01); complete relieving rat was 53.1%. and total effective rat was 78.1%. The officacy rate of leflumomide was 50%. in which 71.9%. There was no significant in the efficact beween mycophenolatemofetil and leflumomide.the side effects of mycophenolate mofetil were lower than those of leflumomide .Conclusion mycophenolate mofetil is a safe and effective medicine in treatment refractory nephropathy syndrome