Effect of Ruhuang preparation on intestinal endotoxemia of liver cirrhosis rats

[Objective]To study the influence of Ruhuang preparation on intestinal endotoxemia of liver cirrhosis rats.[Methods]Sixty male Wister rats were randomly divided into normal group,prevention group,liver cirrhosis model group and model treatment group.Liver cirrhosis model was caused by using CCl4.Prevention group and model treatment group were treated by Ruhuang preparation.All the rats were sacrificed after 10 weeks to detect serum endotoxin,D-lactic acid,DAO and intestinal tract bacterium shifting.[Results] The serum endotoxin level of prevention and model treatment group was apparently lower than liver cirrhosis model group(P0.05).The serum D lactic acid and DAO level of prevention group is obviously lower than liver cirrhosis model group(P0.05),and the level of model treatment group is between the prevention group and model group.Prevention group did not appear intestinal tract bacterium shifting.[Conclusion ]Ruhuang preparation could effectively protect intestines mucous membrane,prevent the increase of intestines permeability,stop intestinal tract bacterium shifting,and reduce intestinal endotoxemia of liver cirrhosis rat.