EXPERIMENTAL STUDY ON THE CHANGES OF SEVERITY OF LIVER CIRRHOSIS AFTER ADJUSTMENT THE INTESTINAL MICROFLORA

Objective:To investigate the relationship batween the intestinal microflora and liver cirrhosis.Methods:50 rats were developed liver cirrhosis models by injected CC14 every day for eight weeks,and at the same time the preventive group and the late treatment group were given Bifico suspension by intragastric feeding daily from the lst and the 6th week respectively.Then liver tissues were examined under the light microcopy and trans-election microscopy after 8 weeks.The intestinal micro flora was cultured for detection of Gram-negative bacteria.Results:(1)There were significant changes in the bacteria numbers between the treatment groups and the model group(P0.05).(2)The hepatocell degeneration and necrosis and delaying the formation of pseudolobe in T group are better than those in C group(P0.05).(3)TEM displayed the height of the intestinal microvilli and the intestinal tight of junction in the preventive treatment group were improved significantly than those in C group.Conclusions:Bifico can adjust intestinal microflora and improved the histology of liver cirrhosis.It suggested that the probiotics might be used for routine auxiliary treatment on the chronic liver diseases.