Application of serum HMGB1 level detection in identification and diagnosis of severe acute pancreatitis

OBJECTIVE To investigate the change of serum HMGB1 level of severe acute pancreatitis and its clinical significance.METHODS Serum HMGB1and CRP and WBC levels were determined in 30 healthy individuals and 45 patients of mild acute pancreatitis and 32 patients of severe acute pancreatitis.The correlation between serum HMGB1 level and serum C-reactive protein level or white blood cell count in acute pancreatitis were analyzed.RESULTS The level of serum HMGB1 and CRP and WBC were significantly higher in patients with severe acute pancreatitis and mild acute pancreatitis than those of the healthy matched control(P0.01).Serum HMGB1 level of the patients of severe acute pancreatitis(16.2±11.28 ng/ml)were significantly above the patients of acute pancreatitis(5.96±3.83ng/ml)(P0.01).There have significant difference of CRP and WBC between the patients of severe acute pancreatitis and the patients of mild acute pancreatitis(P0.05).CONCLUSION Serum HMGB1 level is obviously elevated in the patients of pancreatitis sufferer.The level measurement of the serum HMGB1 is valid index sign which evaluates a pancreatitis pathological changes and respond degree inflammatory reaction.