2007•Zhongguo shiyong erke zazhiRequires access
Expression of Daxx in pediatric acute leukemia and its relationship with expression of NF-κB
Lin Han-hua
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Abstract
Objective To investigate the expression of Daxx in pediatric acute leukemia(AL) and its relationship with expression of NF-κB and clinical significance.Methods The expression of Daxx and NF-κB proteins were detected by immunohistochemical assay in 50 AL children.The control included 20 children with normal bone marrow.Results Daxx protein expression rate was 38.0% and NF-κB protein expression rate was 56.0% in 50 AL children.Both of them were significantly higher than that in control group(P0.05).The expression of Daxx was positively correlated with NF-κB (P0.05).The expression rates of Daxx and NF-κB were 55.6% and 77.8% respectively in HR ALL,0.0% and 16.7% respectively in SR ALL,and the differences were statistically significant (P0.05).Conclusion The over-expression of Daxx and NF-κB may promote tumor genesis and progression in AL.Daxx and NF-κB are also related to some clinical features,treatment outcome and prognostic factors of AL.