Clinical Study on the Effects of Salvianolate Injection on the Levels of Serum 8-isoPG,IL-18 and IL-1β in Acute Exacerbated Chronic Obstructive Pulmonary Disease Patients

OBJECTIVE To investigate the effect of Salvianolate injection on the levels of serum 8-isoPG,IL-18 and IL-1β in acute exacerbated chronic obstructive pulmonary disease(AECOPD) patients.METHODS Sixty patients with AECOPD were randomly assigned to the treatment group and the control group.Routine therapies were given to patients in the control group,while 200 mg Salvianolate injection was given to those in the treatment group by intravenous dripping,once daily for total 14 days.The changes of 8-isoPG,IL-18,IL-1β,the pulmonary functions and CAT scores were evaluated before and after treatment,which was compared with those of 30 healthy controls.RESULTS There were no significant differences in the value of 8-isoPG,IL-18,IL-1β,FEV1/FVC and FEV1% before treatment between two group(P0.05).Compared with the control group,the levels of serum 8-isoPG,IL-18,IL-1β and CAT scores in patient with AECOPD were increased significantly(P0.01).The levels of serum 8-isoPG,IL-18,IL-1β and CAT scores after treatment was significantly lower than that before treatment(P0.01);the levels of 8-isoPG,IL-18,IL-1β and CAT scores decreased more significantly in the salvianolate group after treatment(P0.05).The FEV1% and FEV1/FVC were significantly improved after treatment in two groups(P0.01).There were no significant differences between two group in the levels of FEV1% and FEV1/FVC after treatment(P0.05).CONCLUSION Salvianolate injection can reduce the levels of 8-isoPG,IL-18 and IL-1β and improve the clinical symptoms in AECOPD patients,probably by inhibiting inflammatory reaction and reducing the oxidative stress.