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2009•Xi'an Jiaotong Daxue xuebaoRequires access

Effect of Nbn gene on hippocampus development in postnatal mice

Min Guo

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Abstract

Objective To investigate the role of neuro-specific DNA repair gene Nbn in mouse hippocampus development by observing the morphological differences in Nbn-CNS-Del and Nbn-CNS-Ctr mice.Methods Serial sections and stereology were used to quantitatively analyze the development of mouse hippocampus on postnatal day 7,14 and 21.Results Compared with that of the control group,the hippocampus development of Nbn-CNS-Del mice lagged behind.In Nbn-CNS-Del mice,on day 21,the profile area of pyramidal layer of hippocampus and granular layer of dentate gyrus decreased(P0.05),and the volume densities in granular layer and polymorphic layer of dentate gyrus,and CA4 had significant differences(P0.05).Conclusion DNA repair gene Nbn,an important gene in mouse hippocampus development,affects the development and maturation of hippocampus and granular layer of DG in mice.

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What this paper is about

Objective To investigate the role of neuro-specific DNA repair gene Nbn in mouse hippocampus development by observing the morphological differences in Nbn-CNS-Del and Nbn-CNS-Ctr mice.Methods Serial sections and stereology were used to quantitatively analyze the development of mouse hippocampus on postnatal day 7,14 and 21.Results Compared with that of the control group,the hippocampus development of Nbn-CNS-Del mice lagged behind.In Nbn-CNS-Del mice,on day 21,the profile area of pyramidal layer of hippocampus and granular layer of dentate gyrus decreased(P0.05),and the volume densities in granular layer and polymorphic layer of dentate gyrus,and CA4 had significant differences(P0.05).Conclusion DNA repair gene Nbn,an important gene in mouse hippocampus development,affects the development and maturation of hippocampus and granular layer of DG in mice.

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Available abstract

Objective To investigate the role of neuro-specific DNA repair gene Nbn in mouse hippocampus development by observing the morphological differences in Nbn-CNS-Del and Nbn-CNS-Ctr mice.Methods Serial sections and stereology were used to quantitatively analyze the development of mouse hippocampus on postnatal day 7,14 and 21.Results Compared with that of the control group,the hippocampus development of Nbn-CNS-Del mice lagged behind.In Nbn-CNS-Del mice,on day 21,the profile area of pyramidal layer of hippocampus and granular layer of dentate gyrus decreased(P0.05),and the volume densities in granular layer and polymorphic layer of dentate gyrus,and CA4 had significant differences(P0.05).Conclusion DNA repair gene Nbn,an important gene in mouse hippocampus development,affects the development and maturation of hippocampus and granular layer of DG in mice.

Key concepts: Dentate gyrus, Hippocampus, Stereology, Granular layer, Biology, Neuroscience, Endocrinology, Cerebellum

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