The effect of IL-2 in mouse model with vaginal candidiasis

Objective:To study the effect of IL-2 in mouse model with vaginal candidiasisMethods:63 female Kunming mice were divided into three groups.Group A was infected by Candida alb cans only once,Group B was infected two times and group C was the control group,IL-2 in blood and vaginal fluids were detected and CFU of vaginal fluids was performed after infection of 2,7 and 14 days.The results were processed by SPSS 13.0 statistical software.Results:The content variation of IL-2 and CFU in vaginal fluids was the highest at the 7th.day in both group A and group B,as well as in the blood;there were not notable changes at 2nd.day and 14th.day.The content of IL-2 in group A and group B were all higher than group C.According to the same days post-infection,IL-2 of the group B was higher than that of group A both in vaginal fluids and in blood,and the IL-2 in vaginal fluids was higher in blood.The CFU of group B was higher than group A.Conclusion:Cell-mediated immunity(CMI),as a host defense mechanism,plays an important role in protecting against Candida albicans,especially in secondary infection.Local innate immunity is more important than systemic innate immunity in vulvovaginal candidiasis.IL-2 has protective affection in VVC by promoting local innate immunity level.