Inhibition of Contraction of Isolated Mouse Uterine by Siwu Decoction and It's Composite Drugs

Objective:To study the effects of Siwu decoction and its composite drugs on isolated mouse uter-ine contraction in vitro.Methods:The model of isolated mouse uterus contraction was adopted and the inhibition rates of mean contraction force,constriction amplitude,constriction frequency were calculated to evaluated the influ-ence of Siwu decoction and its composite drugs.Result:Siwu decoction and its composite drug-pairs and drugs had certain pharmacological effect on the isolated mouse uterine contraction in vitro,by suppressing the mean contraction force,constriction amplitude and constriction frequency.Conclusion:Angelicae Sinensis Radix and Paeoniae Radix Alba may be the most significant drugs to the model of isolated mouse uterine contraction.The two drugs had syner-getic effect with each other on this activity;Rehmanniae Radix Praeparata and Angelicae Sinensis Radix also had synergetic effect with each other on the activity of suppressing the constriction of isolated mouse uterine;This study provides a reliable reference for the follow-up study.