ScholarLens Back to search
2004•Zhonghua weichan yixue zazhiRequires access

The level of serum leptin in GDM mothers and their neonates and the expression of leptin in placenta

Tong Liu

Open publisher page 0 citations

Abstract

Objective To investigate the level of leptin in the serum of GDM mothers and their neonates and the variation of the leptin expression in placenta. Methods The concentrations of serum insulin and leptin in 24 GDM and 26 healthy mothers and neonates were examined by radioimmunoassay (RIA).The level of leptin mRNA in 50 placentas was examined by reverse transcription-polymerase chain reaction(RT-PCR). Results (1) The serum levels of leptin and insulin in GDM group [(18.62±7.86) μg/L and (13.47±5.11) mIU/L] were significantly higher than those in control group [(14.21±7.59) μg/L and (8.98±4.23) mIU/L,P 0.05]. (2)The levels of leptin and insulin in the umbilical blood of the GDM group [(17.93±6.14) μg/L and (19.26±6.73) mIU/L]were significantly higher than those in control group [(7.27 ±4.32) μg/L and (9.67±4.89) mIU/L, P 0.01]. (3)The leptin level of maternal serum was not related to the insulin level ( r= 0.22,P 0.05) in both groups. But the leptin level in umbilical blood of the two group was positively related to the insulin level ( r=0.53,P 0.01). (4)The level of leptin mRNA in placenta of GDM group was (1.92±0.05),which was significantly different to the control group(0.97±0.02,P 0.01 ). Conclusion The resistance to insulin and leptin may be one of the major causes of GDM. Insulin plays an important role in regulating the expression of leptin in placenta.

About this research paper

What this paper is about

Objective To investigate the level of leptin in the serum of GDM mothers and their neonates and the variation of the leptin expression in placenta. Methods The concentrations of serum insulin and leptin in 24 GDM and 26 healthy mothers and neonates were examined by radioimmunoassay (RIA).The level of leptin mRNA in 50 placentas was examined by reverse transcription-polymerase chain reaction(RT-PCR). Results (1) The serum levels of leptin and insulin in GDM group [(18.62±7.86) μg/L and (13.47±5.11) mIU/L] were significantly higher than those in control group [(14.21±7.59) μg/L and (8.98±4.23) mIU/L,P 0.05]. (2)The levels of leptin and insulin in the umbilical blood of the GDM group [(17.93±6.14) μg/L and (19.26±6.73) mIU/L]were significantly higher than those in control group [(7.27 ±4.32) μg/L and (9.67±4.89) mIU/L, P 0.01]. (3)The leptin level of maternal serum was not related to the insulin level ( r= 0.22,P 0.05) in both groups. But the leptin level in umbilical blood of the two group was positively related to the insulin level ( r=0.53,P 0.01). (4)The level of leptin mRNA in placenta of GDM group was (1.92±0.05),which was significantly different to the control group(0.97±0.02,P 0.01 ). Conclusion The resistance to insulin and leptin may be one of the major causes of GDM. Insulin plays an important role in regulating the expression of leptin in placenta.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the level of leptin in the serum of GDM mothers and their neonates and the variation of the leptin expression in placenta. Methods The concentrations of serum insulin and leptin in 24 GDM and 26 healthy mothers and neonates were examined by radioimmunoassay (RIA).The level of leptin mRNA in 50 placentas was examined by reverse transcription-polymerase chain reaction(RT-PCR). Results (1) The serum levels of leptin and insulin in GDM group [(18.62±7.86) μg/L and (13.47±5.11) mIU/L] were significantly higher than those in control group [(14.21±7.59) μg/L and (8.98±4.23) mIU/L,P 0.05]. (2)The levels of leptin and insulin in the umbilical blood of the GDM group [(17.93±6.14) μg/L and (19.26±6.73) mIU/L]were significantly higher than those in control group [(7.27 ±4.32) μg/L and (9.67±4.89) mIU/L, P 0.01]. (3)The leptin level of maternal serum was not related to the insulin level ( r= 0.22,P 0.05) in both groups. But the leptin level in umbilical blood of the two group was positively related to the insulin level ( r=0.53,P 0.01). (4)The level of leptin mRNA in placenta of GDM group was (1.92±0.05),which was significantly different to the control group(0.97±0.02,P 0.01 ). Conclusion The resistance to insulin and leptin may be one of the major causes of GDM. Insulin plays an important role in regulating the expression of leptin in placenta.

Key concepts: Leptin, Internal medicine, Endocrinology, Radioimmunoassay, Insulin, Placenta, Medicine, Insulin resistance

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The level of serum leptin in GDM mothers and their neonates and the expression of leptin in placenta — Research Paper | ScholarLens