Expression changes of pSTAT3,cyclin D1 and VEGF in cervical squamous cell carcinoma

Objective To observe the expression changes of phosphorylated signal transducer and activator of transcription 3(pSTAT3),cyclin D1 and vascular endothelial growth factor(VEGF) in cervical squamous cell carcinoma and to discuss their clinical significance. Methods The expression of pSTAT3,cyclin D1 and VEGF proteins in 40 cases of cervical squamous cell carcinoma( SCC group),20 cases of cervical intraepithelial neoplasia( CIN group),and 15 cases of normal cervical squamous epithelium( NE group) was detected respectively by immunohistochemical SP method. Results The overexpression rates of pSTAT3 in the SCC and CIN groups were 20. 0% and 62. 5%,the overexpression rates of cyclin D1 were 30. 0% and 72. 5%,and VEGF were 40. 0% and 82. 5%,respectively( all P 0. 05). There was no overexpression of all in the NE group. The overexpression of pSTAT3 and cyclin D1 was related to pathological grade,clinical stage and lymph node metastasis( both P 0. 05). The overexpression of VEGF was related to pathological grade and lymph node metastasis( all P 0. 05). The expression of pSTAT3 was positively correlated with that of cyclin D1( r = 0.531,P 0. 05) and VEGF( r = 0. 618,P 0. 05) in the cervical squamous cell carcinoma. Conclusion The expression of pSTAT3,cyclin D1 and VEGF increases in the cervical squamous cell carcinoma tissues,which might contribute to the development and progression of cervical carcinoma.