The clinical study on the triple therapy for the eradication of Helicobacter pylori infection

Objective In order to observe the efficacies on eradicating Helicobacter pylori(HP) and healing duodenal ulcer(DU), and to choose ideal triple therapeutic regimen that mainly include omeprazole and clarithromycin,and metronidazole.Methods 184 patients with DU were infected by HP diagnosed by gastroscope,histology and 14C urea breath test. All patients were allocated randomly into group A and group B.Group A:omeprazole 20 mg bid, clarithromycin 250 mg bid and metronidazole 400 mg bid; Group B:omeprazole 20 mg bid, clarithromycin 250 mg bid and furanzolidone 100 mg bid.The course of therapy were 7 days. After 4 weeks of discontinuing these pills, the results of HP eradication, status of ulcer healing and side effects were checked and recorded.Results The total rates of ulcer healing in group A was 91.4%, in group B was 92.3%. The HP eradication rate in group A and B were 90.3% and 93.4% respectively.The differences between the two regimens weren't significant(P0.05).Significant differences in mild side effects were observed (P0.05) which were 16.1% and 4.4% in group A and group B,respectively.Conclusions Two groups that include PPI triple therapeutic regimens can effectively eradicate HP and heal DU.Furanzolidone possesses the advantages of good efficacy,no resistance,cheap and mild side effects.So it could replace metronidazole to be used in the triple therapeutic regimens along with omeprazole and clarithromycin.It is suitable to the native condition.