Detection of pathogenic bacteria causing respiratory tract infections in children at excerbation stage of bronchial asthma and analysis of drug resistance

OBJECTIVE To analyze the distribution and drug resistance of the pathogenic bacteria causing respiratory tract infections in the children at exacerbation stage of bronchial asthma so as to guide the reasonable clinical use of antibiotics.METHODS The clinical data of 143children at exacerbation stage of bronchial asthma who were treated in the hospital from Aug 2009to Sep 2011were retrospectively analyzed,the secretions collected from the respiratory tracts were performed for etiological test,then the distribution and the drug resistance were analyzed.RESULTS Totally 87strains of viruses were isolated,among which the syncytial virus was dominant with the detection rate of 33.3%,significantly higher than other species of pathogens(P0.05),the influenza B virus,influenza A virus,and adenovirus were the other species of viruses,accounting for 19.4%,18.4%,and 12.7%,respectively;totally 63strains of pathogens were isolated,among which there were 24strains of Klebsiella pneumoniae,the detection rate was 38.1%,significantly higher than other species of pathogens,other major species of pathogens included Escherichia coli,Staphylococcus aureus,and Streptococcus pneumoniae,accounting for 22.2%,14.3%,and 12.7%,respectively.The drug susceptibility testing indicated that the drug resistance rates of the E.coli,S.aureus,and S.pneumoniae to meropenem,imipenem,and amikacin were less than 4.2%,the drug resistance rate to compound sulfamethoxazole was the highest(more than 66.7%),the drug resistance rates of S.aureus,and S.pneumonia to compound sulfamethoxazole were the highest(more than 62.5%),and the strains have produced certain drug resistance to other commonly used antibiotics.CONCLUSION There are many predisposing factors of the attach of bronchial asthma,it is necessary to determine the type of respiratory tract infections before the treatment with the accurate and rapid detection method.For the children with mixed viral infections,the antivirus therapy is recommended on the basis of use of antibiotics so as to prevent the respiratory tract infections.