Effect of Itopride in treatment of chronic constipation patients

Objective To evaluate the efficacy of Itopride in treatment of chronic constipation patients.Methods Eighty-four consecutive patients with chronic constipation who had been divided into three groups(slow transit constipation,outlet obstructed constipation and mixed type constipation) according to their pathophysiological characteristics received treatments with Itopride for two weeks.The efficacy of treatment was determined and the causes of constipation were analyzed.Results GITT in chronic constipation patients after 2 weeks therapy were all shorter than pretreatment(P0.05).There was no difference of anorectal motility and rectal visceral perception to balloon distention in patients with chronic constipation before and after 2 weeks therapy.The symptom scores of constipation in STC patients after 2 weeks therapy were all lower than pretreatment(P0.05).The symptom scores of constipation in OOC patients after 2 weeks therapy had no difference than pretreatment(P0.05).The symptom scores of constipation in STC patients after 2 weeks therapy were all lower than pretreatment(P0.05).The scores of defecate frequence in MTC patients after 2 weeks therapy were lower than pretreatment(P0.05),the others had no change.Conclusion The patients of STC benefited from the Itopride treatments significantly than OOC and MTC.