The Therapeutic Effect of Small Doses Doxycycline Combine Metronidazole Gel for Rosacea

Objective To observe the clinical efficacy and safety of small doses doxycycline combined with topical metronidazole gel in the treatment of rosacea. Methods Ninety cases of rosacea were divided randomly into three groups,the treatment group(n=30) were given doxycycline 20mg orally plus 0.75% metronidazole gel topically twice a day. The control group 1(n=30)only orally took doxycycline 20mg two times per day,and the control group 2 (n=30)only applied 0.75% metronidazole gel twice a day. All groups had been given four-week courses. Results Total efficiency in the treatment group was 96.55%, which was better than that of control group 1 (75.00%)and the control group 2(76.67%)(P0.05);There was no satistical diffrence between the control group 1 and the control group 2(P0.05). Mild local desiccation occured equally in both the treatment group and the control group 2, adverse reaction rate were 10.34% in the treatment group and 13.33% in the control group 2. Adverse reaction was not be founded in the control group 1. Conclusion The combination therapy of small doses of doxycycline and topical metronidazole gel is safe and effective in the treatment of rosacea.