The change of plasma adiponectin level and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage

Objective:To detect the change of plasma adiponectin and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage.Methods: Blood samples of 30 cases in control group and 43 patients with hypertensive cerebral hemorrhage were obtained 1,2,3,5,and 7 days after hospitalization.Enzyme-linked immunosorbent assay(ELISA) and radioimmunoassay were used to measured concentrations of plasma adiponectin,interleukin-6(IL-6),C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α).Results: After hypertensive cerebral hemorrhage,the level of plasma adiponectin increased immediately within 6 h,reached the peak at 24 h,and decreased gradually after 2 days.The adiponectin concentration was higher in patients with hypertensive cerebral hemorrhage than control group during 7 days.The levels of plasma IL-6,CRP,and TNF-α in patients with hypertensive cerebral hemorrhage were significantly higher than those in control group,and were associated with adiponectin level.Conclusion: The change of plasma adiponectin was a dynamic process.Together with IL-6,CRP,and TNF-α,plasma adiponectin may be involved in the inflammatory responses injury after cerebral hemorrhage.