Effect of a low dose of Diuretic in patient with essential hypertension assessed by ambulatory blood pressure

Purpose:To Assess the efficacy of diuretic in reducing high blood pressure,systolic blood pressure(SBP) of the old patients in particular.Methods: 20 patients with class III hypertension begin their initial medication with at least 2 kinds of drugs to reduce their blood pressure but the blood pressure control is still not ideal.Adding a low dose of diuretic of hydrochlorothiazide 6.25mg～12.5mg/d or amiloride1.25mg～2.5mg/d once daily at 6am.Taking physical examination by making ABPM and laboratory investigation 2 weeks before and after taking the diuretic.Results:ABPM shows that the average(24-hour,daytime and nighttime) SBP/DBP is reduced respectively by 15.1±7.9/7.2±4.2 mmHg、14.1±9.6/6.8±5.4 mmHg and 17.5±11.7/7.8±6.6 mmHg.The T/P ratio is SBP61%,DBP 63%.No serious adverse reactions.Conclusions: The efficacy of low-dose diuretic on reducing blood pressure is remarkable,effective and stable.