Comparison of adjuvants for rabies inactivated vaccines

Recombinant HEP-dG rabies virus strain was rescued by the technique of reverse genetics,three inactivated rabies vaccines with aluminum-adjuvant,oil-adjuvant and propolis adjuvant were used to vaccine mice.The results demonstrated that both oil-adjuvant inactivated and propolis-adjuvant vaccine could enhance high levels of antibodies.The antibody after boost with propolis adjuvant inactivated rabies vaccine was higher than that of the single immuned propolis adjuvant one.The levels of antibodies after the single immunized oil-adjuvant inactivated rabies vaccine were equivalent to that of mice after boost with propolis adjuvant inactivated rabies vaccine.Recombinant HEP-dG rabies virus strain has good immunogenicity,and the oil-adjuvant was the optimum adjuvant for HEP-dG rabies virus.