Clinical observation of cefoperazone sulbactam combined with levofloxacin in the treatment of HAP

Objective To investigate the clinical efficacy and adverse reactions of the cefoperazone sulbactam combined with levofloxacin in the treatment of hospital acquired pneumonia( HAP). Methods Forty-two patients with HAP were randomly divided into treatment group and control group,each group with 21 patients. The treatment group was treated with cefoperazone sulbactam combined with levofloxacin and control group was treated with cefoperazone sulbactam,treatment course was 7 ~ 8 d. Results The time of symptoms and sign returned to normal in the treatment group was( 48. 24 ± 7. 54) h,that in the control group was( 72. 36 ± 10. 24) h( P 0. 01); the clinical efficacy of the treatment group was better than the control group( P 0. 05),incidence of adverse reactions was not statistically significant between the two groups( P 0. 05). Conclusion The efficacy of cefoperazone sulbactam combined with levofloxacin in the treatment of HAP is significantly better than cefoperazone sulbactam,and this combined use is worthy of promotion.