2006•Journal of RadioimmunologyRequires access

Significance of Changes of Serum TPOAb and TRAb Levels in Patients with Graves' Disease (GD)

Pla Nanjing

Abstract

Objective To investigate the significance of changes of serum TPOAb and TRAb levels in patients with Graves' disease(GD). Methods Serum TPOAb(with RIA) and TRAb(with RRA) levels were determined in 27 patients with Graves' disease,before treatment 10 patients with Graves' disease clinically cured and 35 controls.Results The serum levels and positive rates of TPOAb and TRAb in patients with Graves' disease before treatment were significantly higher than those in the patients with Graves' disease clinically cured and controls(P0.01).Conclusion TPOAb and TRAb were involved in the pathogenesis of Graves' disease and could be used as diagnostic and treatment indicators.

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Key concepts: Trab, Graves' disease, Medicine, Internal medicine, Pathogenesis, Disease, Endocrinology, Clinical significance