The relationship of serum resistin and plasma glucose, lipidemia as well as insulin resistance in type 2 diabetes

Objective To study the relationship between serum resistin concentrations with type 2 diabetes and plasma glucose , lipidemia as well as insulin resistance. Methods Fasting serum resistin concentration was measured by enzyme immunoassay in 52 cases suffering from T2DM, obesity (BMI≥ 25 kg/m2)(26 subjects) and non- obesity ( BMI 25 kg/m2)( 26 subjects) were subgrouped on BMI and 17 cases non- diabetic controls with normal glucose tolerance, HOMA- IR were calculated. Meanwhile, OGTT and insulin release test and lipidemia were conducted, blood pressure, height, other data including body weight, waist circumference and hip circumference were measured to calculate BMI and waist- hip ratio (WHR). Results The fasting serum resistin concentration (ng/mL) were higher in obese T2DM than that in those persons with lean T2DM (P 0.01), in obese T2DM resistin was higher than that in those in non- diabetic group(control group), resistin in control group was slightly higher than normal weight in diabetic group, but difference was not statistical significance( P 0.05) .The fasting resistin was significantly increased in famine.Correlate analysis showed that fasting serum resistin concentration was a positive correlated with BMI, HOMA- IR, fasting insulin, postprandial 2h insulin and triglyceridemia( r=0.403, r=0.337, r=0.652, r=0.428, P 0.001; r=0.320, P 0.01). The fasting serum resistin concentration was a negative correlated with postprandial 2h plasma glucose( r= - 0.303, P 0.05). No correlation between resistin and fasting glucose ,blood pressure, WHR, age, cholesterol, high density lipoprotein, low density lipoprotein were found. Conclusion There are markedly higher in resistin levers in T2DM with obese and fasting serum resistin level was correlated with BMI, FINS, 2h INS, HOMA- IR, 2h PG and TG. Resistin may play a role in the insulin resistance during the developing of obesity to diabetes. Resistin might be result in hypertriglyceridemia.