Local arterial infusion therapy for 20 cases of acute necrotizing pancreatitis

Objective To evaluate the intra-arterial infusion of pancreatic enzyme inhibitor and antibiotics in the treatment of acute necrotizing pancreatitis(ANP).Methods Twenty patients with ANP were treated with arterial infusion by placing a cather in the celiac artery,spleen artery or gastroduodenal artery.Octreotide and antibiotics was used continuously for 6 to 14 days.According to the site of the inflamnation on the CT scan,the top of the catheter was set in the celiac in 10 cases and gastroduodenal artery in 10 cases.Results The mortality rate in this study was 0 and no procedure related complication was observed.Nineteen of 20 patients had good effect,without severe complication.In one case,drainage of parapancreatic abscess was performed after local arterial infusion(LAI) for pancreatic pseudcyst.Conclusion LAI therapy of octreotide and antibiotics for ANP offers good therapeutic effect.