Pharmaceutical Evalution of Injectable Shenmai Temperature-sensitive in Situ Gel

Objective:To prepare injectable Shenmai thermosensitive in situ gel and to investigate its in vitro release characteristics.Method: Shenmai thermosensitive in situ gel was prepared by cold dissolution method,the content of ginsenoside Rb1 was determined by HPLC,in vitro release characteristics of Shenmai thermosensitive in situ gel was investigated by dialysis method,and release curve was fitted by drug release model equation.Result: Gelation temperature was 34.92 ℃,corresponding viscosity value was 1 579.52 mPa·s,gelation time was 110.67 s.This in situ gel showed a newtonian fluid at a low temperature while it might be a pseudoplastic fluid when the temperature reached a certain point,in vitro release of Shenmai thermosensitive in situ gel fitted first order kinetics equation.Conclusion: Shenmai thermosensitive in situ gel had temperature sensitivity and obviously sustained-release effect.