Clinical study of mycophenolate mofetil treatment in HBV associated glomerulonephritis

Objective To investigate the efficacy and the adverse effect of mycophenolate mofetil(MMF)in HBV associated glomerulonephritis.Methods Twenty patients with HBV-GN diagnosed by renal biopsy were treated with MMF.The initial dosage of MMF was 1.5 g/d.The dosage was reduced to 1.0 g/d when 24 h excretion of urinary protein decreased to 0.5 g/d.Blood routine test,hepatic and renal function,plasma albumin,serum triglyceride and cholesterol,24 h urinary protein excretion,HBV DNA were performed before and after 2,3,6,9 months' treatment.Results Twenty-four-hour urinary protein excretion was significantly reduced by the treatment with mycophenolate mofetil(P0.01).The serum albumin was significantly improved(P0.05).Serum creatinine,triglyceride and cholesterol were remarkably reduced(P0.05).The reproduction of HBV didn't increase.Nine cases had fully remission and the total effective rate was 85% after 9 months' treatment.There were no serious adverse effects during the period of administrating the drugs.Conclusion The therapy of MMF is effective in HBV-associated glomerulonephritis with less adverse effect.