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2005•Jiangsu Medical JournalRequires access

Effect of atorvastatin on mesangial cells cultured in high concentration of glucose

Jian Xiuqin

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Abstract

Objective To investigate the protective effects and mechanisms of atorvastatin in the patients with diabetic nephropathy.Methods The effects of atorvastatin on the proliferation,the expression of AM mRNA,TGF-β_1 mRNA and content of AM,AngⅡ,laminin,type Ⅳ collagen,~fibronectin of the cultured human mesangial cells under high glucose condition were observed in vitro.Results Atorvastatin had a significant inhibition of the expression of TGF-β_1 mRNA and AM ~mRNA and the proliferation of the mesangial cells cultured under high glucose condition,and could also decrease the concentrations of TGF-β_1,AM,AngⅡ,laminin and type Ⅳ collagen in the matrixes.~Conclusion Atorvastatin has renal protective property that was associated with its suppression on the expression of TGF-β_1 and the proliferation of human mesangial cell cultured under high glucose conditions.The expression and secretion of AM decreased as the expression and secretion of AngⅡ and TGF-β_1 declined.

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Objective To investigate the protective effects and mechanisms of atorvastatin in the patients with diabetic nephropathy.Methods The effects of atorvastatin on the proliferation,the expression of AM mRNA,TGF-β_1 mRNA and content of AM,AngⅡ,laminin,type Ⅳ collagen,~fibronectin of the cultured human mesangial cells under high glucose condition were observed in vitro.Results Atorvastatin had a significant inhibition of the expression of TGF-β_1 mRNA and AM ~mRNA and the proliferation of the mesangial cells cultured under high glucose condition,and could also decrease the concentrations of TGF-β_1,AM,AngⅡ,laminin and type Ⅳ collagen in the matrixes.~Conclusion Atorvastatin has renal protective property that was associated with its suppression on the expression of TGF-β_1 and the proliferation of human mesangial cell cultured under high glucose conditions.The expression and secretion of AM decreased as the expression and secretion of AngⅡ and TGF-β_1 declined.

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Available abstract

Objective To investigate the protective effects and mechanisms of atorvastatin in the patients with diabetic nephropathy.Methods The effects of atorvastatin on the proliferation,the expression of AM mRNA,TGF-β_1 mRNA and content of AM,AngⅡ,laminin,type Ⅳ collagen,~fibronectin of the cultured human mesangial cells under high glucose condition were observed in vitro.Results Atorvastatin had a significant inhibition of the expression of TGF-β_1 mRNA and AM ~mRNA and the proliferation of the mesangial cells cultured under high glucose condition,and could also decrease the concentrations of TGF-β_1,AM,AngⅡ,laminin and type Ⅳ collagen in the matrixes.~Conclusion Atorvastatin has renal protective property that was associated with its suppression on the expression of TGF-β_1 and the proliferation of human mesangial cell cultured under high glucose conditions.The expression and secretion of AM decreased as the expression and secretion of AngⅡ and TGF-β_1 declined.

Key concepts: Atorvastatin, Internal medicine, Endocrinology, Fibronectin, Laminin, Secretion, Mesangial cell, Messenger RNA

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