2012•Zhongguo shiyan fangjixue zazhiRequires access

Effect of Azone on in vitro Transdermal Absorption of Puerarin from Guping Cataplasmata

Chao Zhang

Abstract

Objective:To study on effect of azone on in vitro transdermal absorption of puerarin from Guping cataplasmata.Method:Transdermal absorption of puerarin was investigated by Franz diffusion pool method when used by azone alone or combination of azone and other penetration enhancers.Result:Transdermal absorption of puerarin could be enhanced by different concentration of azone,especially when azone combined with camphol and volatile oil in this prescription.Conclusion:Added 5% azone in Guping cataplasmata could remarkably increase absorption rate and absorbing capacity of puerarin.

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Key concepts: Azone, Puerarin, Transdermal, Chemistry, Chromatography, Absorption (acoustics), Penetration (warfare), Pharmacology