Ondansetron plus dexamthasone in anti-emesis induced by cisplatin containing chemotherapy

Purpose:To evaluate the efficacy of ondansetron plus dexamethasone compared with metoclopramide plus dexamethasone against emesis induced by cisplatin (DDP) containing chemotherapy.Methods:53 malignant tumor patients received DDP containing chemotherapy. DDP was 20 mg/m 2 ,qd,from the first day to the fifth day;ondansetron was 4 mg plus dexamethasone 5 mg,qd,from the first day to the fifth day; metoclopramide was 10 mg plus dexamethasone 5mg,qd,from the first day to the fifth day. Results:The anti emetic rate of ondansetron plus dexamethasone was 82.6%,which was higher than that of metoclopramide plus dexamthasone (44.5%, P 0.01).Conclusions:The anti emetic effect of ondansetron plus dexamethasone was better than that of metoclopramide plus dexamethasone against emesis induced by DDP containing chemotherapy. It may have a future role in clinical usage.