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2008•Acta Academiae Medicinae JiangxiRequires access

Detection and Significance of Serum Interleukin-8 in Chronic Obstructive Pulmonary Disease

Qiugen Li

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Abstract

Objective To evaluate the role of interleukin-8 in the pathogenesis of COPD.Methods The serum levels of IL 8 were evaluated by ELISA method from 30 patients with acute exacerbation of COPD and the patients after therapy to stable phase and 10 healthy control subjects.Also their pulmonary function and the percentage of neutrophils were evaluated.Results The percentage of neutrophils and the level of IL-8 in serum from acute exacerbation of COPD patients were significantly higher than those from stable COPD patiens and from healthy control subjects(P0.05).FEV1% correlated negatively with IL-8 from acute exacerbation of COPD and stable COPD(r=-0.96,P0.01,r=-0.77,P0.01).Conclusion IL-8 is involved in airway inflammation witch results in airflow obstruction.IL-8 is an important role in COPD patiens.

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What this paper is about

Objective To evaluate the role of interleukin-8 in the pathogenesis of COPD.Methods The serum levels of IL 8 were evaluated by ELISA method from 30 patients with acute exacerbation of COPD and the patients after therapy to stable phase and 10 healthy control subjects.Also their pulmonary function and the percentage of neutrophils were evaluated.Results The percentage of neutrophils and the level of IL-8 in serum from acute exacerbation of COPD patients were significantly higher than those from stable COPD patiens and from healthy control subjects(P0.05).FEV1% correlated negatively with IL-8 from acute exacerbation of COPD and stable COPD(r=-0.96,P0.01,r=-0.77,P0.01).Conclusion IL-8 is involved in airway inflammation witch results in airflow obstruction.IL-8 is an important role in COPD patiens.

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Available abstract

Objective To evaluate the role of interleukin-8 in the pathogenesis of COPD.Methods The serum levels of IL 8 were evaluated by ELISA method from 30 patients with acute exacerbation of COPD and the patients after therapy to stable phase and 10 healthy control subjects.Also their pulmonary function and the percentage of neutrophils were evaluated.Results The percentage of neutrophils and the level of IL-8 in serum from acute exacerbation of COPD patients were significantly higher than those from stable COPD patiens and from healthy control subjects(P0.05).FEV1% correlated negatively with IL-8 from acute exacerbation of COPD and stable COPD(r=-0.96,P0.01,r=-0.77,P0.01).Conclusion IL-8 is involved in airway inflammation witch results in airflow obstruction.IL-8 is an important role in COPD patiens.

Key concepts: COPD, Exacerbation, Medicine, Pathogenesis, Pulmonary disease, Internal medicine, Pulmonary function testing, Inflammation

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Detection and Significance of Serum Interleukin-8 in Chronic Obstructive Pulmonary Disease — Research Paper | ScholarLens