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2009•Asian Journal of EcotoxicologyRequires access

Anti-Estrogenic Effects of Complex Extracts Containing Polybrominated Diphenyl Ethers from Biotic Samples

Xu Xiaobai

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Abstract

In order to explore preliminarily the potential risk of the complex pollutants containing polybrominated diphenyl ethers(PBDEs)from biotic samples from E-waste treating areas,the complex pollutants containing PBDEs were extracted from Sanhuang chicken samples from an E-waste recycling region.Human breast cancer MCF-7 cells and MDA-MB-231 cells were exposed to the extracts for 6d,and the cell proliferation and mRNA expression of pS2,an estrogen-target gene,were determined.Results showed that the extracts had no cytotoxic effects but suppressed significantly the cell proliferation and mRNA expression of pS2 in MCF-7 cells.The extracts exhibited anti-estrogenic activity.The results suggest that complex pollutants containing PBDEs from E-waste recycling regions have certain potential risk for animal and human health.

About this research paper

What this paper is about

In order to explore preliminarily the potential risk of the complex pollutants containing polybrominated diphenyl ethers(PBDEs)from biotic samples from E-waste treating areas,the complex pollutants containing PBDEs were extracted from Sanhuang chicken samples from an E-waste recycling region.Human breast cancer MCF-7 cells and MDA-MB-231 cells were exposed to the extracts for 6d,and the cell proliferation and mRNA expression of pS2,an estrogen-target gene,were determined.Results showed that the extracts had no cytotoxic effects but suppressed significantly the cell proliferation and mRNA expression of pS2 in MCF-7 cells.The extracts exhibited anti-estrogenic activity.The results suggest that complex pollutants containing PBDEs from E-waste recycling regions have certain potential risk for animal and human health.

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Available abstract

In order to explore preliminarily the potential risk of the complex pollutants containing polybrominated diphenyl ethers(PBDEs)from biotic samples from E-waste treating areas,the complex pollutants containing PBDEs were extracted from Sanhuang chicken samples from an E-waste recycling region.Human breast cancer MCF-7 cells and MDA-MB-231 cells were exposed to the extracts for 6d,and the cell proliferation and mRNA expression of pS2,an estrogen-target gene,were determined.Results showed that the extracts had no cytotoxic effects but suppressed significantly the cell proliferation and mRNA expression of pS2 in MCF-7 cells.The extracts exhibited anti-estrogenic activity.The results suggest that complex pollutants containing PBDEs from E-waste recycling regions have certain potential risk for animal and human health.

Key concepts: Polybrominated diphenyl ethers, Pollutant, Polybrominated Biphenyls, Environmental chemistry, Chemistry, Organic chemistry

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